Res was purchased from Selleck chemicals (Dallas, TX., USA). The purity as determined by HPLC was 99.73%. Pluronic F127 was purchased from Sigma-Aldrich (St. Louis, MO., U.S.A), coumarin 6 (MW 350.43) from Santa Cruz Biotechnology (Dallas, TX, USA) and D-Alpha Tocopheryl Polyethylene Glycol 1000 Succinate (Vitamin E TPGS) from Eastman Chemical Company (Kingsport, TN, USA). Acetone (ACS grade) and Dichloromethane anhydrous (purity ≥ 99.8 %) were purchased from Sigma-Aldrich and Dimethyl Sulfoxide, extra pure (99.9%) from Scharlau chemicals (Barcelona, Spain).

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