Because RCTs on SARS or MERS performed to date were not sufficient, any RCT, study in prospective or retrospective cohort design, case-control design, or case series published as an article in a scientific journal were eligible. In the case of non-RCTs, studies with a total of 10 or more patients were included, except for relatively rare treatment forms that had not been administered in dozens of patients to date. For COVID-19, only RCTs were eligible except of studies included in a meta-analysis.

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