IPA software (https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis/) was used to catalog proteins in different functional categories. Statistical significance (P value) was determined with 5% false discovery rate cutoff, as instructed by the supplier (http://qiagen.force.com/KnowledgeBase/KnowledgeIPAPage#). Molecular and cellular functions for each category are defined at http://qiagen.force.com/KnowledgeBase/KnowledgeIPAPage?id=kA1D0000000PIokKAG. Proteins in each category were then analyzed for their functional/physical interactions with the cutoff of confidence score of 0.700 using STRING version 11.0 software (67). Identified interaction clusters were visualized using the Markov cluster (MCL) algorithm (inflation parameter = 3.0) (68). The overlap between interactomes was determined using jvenn (69).

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