A-674563, carboplatin, FRAX1036, and PF-03758309 were purchased from Selleckchem. BDP5290 and BDP9066 were purchased from Glixx Laboratories and ProbeChem, respectively (data file S10). For the compounds used in MIB synthesis, purvalanol B was purchased from Abcam. PP58 (42) and VI16832 (43) were custom-synthesized according to previously described methods by The Center for Combinatorial Chemistry and Drug Discovery, Jilin University, P.R. China. CTx-0294885 (44) was purchased from MedKoo Biosciences Inc. (406457). Conjugation of inhibitors to beads was performed by carbodiimide coupling to ECH Sepharose 4B (CTx-0294885, VI16832, and PP58) or EAH Sepharose 4B (purvalanol B) (GE Healthcare).

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