Ovarian tumors from 28 chemo-naïve patients with stage III or IV HGSOC were obtained from the FCCC BRF for this Institutional Review Board–approved research (16-9031 and 14-809). Tumor tissue was snap-frozen at the time of collection and stored at −80°C in the FCCC BRF. Tumor histology and cellularity were confirmed by the FCCC BRF pathologist at the time of banking. Tumors isolated from HGSOC PDX models were snap-frozen and stored at −80°C until sample processing for MIB-MS analysis. A description of patient tumors and PDX tumor tissue details can be found in data file S2.

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