Two-tailed Student’s t tests and one-way analysis of variance (ANOVA) with Bonferroni post tests were used as appropriate. Changes in fEPSP slope before and during drug add (peak effect) were compared using a paired t test. For all statistical comparisons, the critical P value was considered to be 0.05. The numbers of animals to be used for each experiment outlined within the study were determined using a power calculation statistical analysis using the Power and Sample Size Calculation software program available at Vanderbilt University (Dupont and Plummer, PS Controlled Clinical Trials. 18:274 1997). Animal numbers are based on a power calculation using SEs from published studies and previous experience to detect >20% difference for each outlined experiment with an 80% power (α = 0.05, power = 80%, δ = 0.2, σ = 0.18).

Note: The content above has been extracted from a research article, so it may not display correctly.



Q&A
Please log in to submit your questions online.
Your question will be posted on the Bio-101 website. We will send your questions to the authors of this protocol and Bio-protocol community members who are experienced with this method. you will be informed using the email address associated with your Bio-protocol account.



We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.