Statistical analyses were performed using Prism software version 7.0 (GraphPad). Experiments are reported as means ± SEM as noted in the legends. Data were analyzed using a two-tailed Student’s t test for comparison between two datasets. Multiple comparisons were analyzed by two-way ANOVA, followed by Tukey’s multiple-comparison correction. A P value of less than 0.05 was considered statistically significant. Every immunoblot experiment was performed three times. Drug response curves and cell viability experiments were performed three times with three replicates each for each dose.

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