All experimental procedures were performed under a protocol approved by the Institutional Animal Care and Use Committee at the University of Alabama at Birmingham. Six-month-old NTG and hAPPJ20 mice [B6.Cg-Zbtb20Tg(PDGFB-APPSwInd)20Lms/2Mmjax] (MMRRC stock no: 34836-JAX J20, the Jackson Laboratory) were treated once daily with mock (90% H20 and 10% DMSO) or SR7826 (dissolved in 90% H20 and 10% DMSO) for 11 days via oral gavage using plastic gavage tips (Instech, catalog no. FTP-20-38). Treatment was given at 2:00 p.m. daily throughout the entirety of the treatment regimen. SR7826 was dissolved fresh each day at a concentration of 10 mg/kg (200 μl total volume per animal per day). Mice were euthanized at the end of the treatment period for postmortem analyses. For all experiments, age-matched and sex-matched animals were used. When necessary, additional details on mouse sex are provided in figure legends.

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