Statistical tests and n numbers for each figure are given in the figure legends. Datasets were tested for normality with the D’Agostino and Pearson omnibus normality test. The Mann-Whitney test, the Kruskal-Wallis with Dunn’s multiple comparisons test, the Wilcoxon signed-rank test, and Akaike’s information criteria (AICc) were all calculated with GraphPad Prism 7.01 software. The Fisher’s exact test was performed with an online tool (

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