[3H]Ketanserin, [3H]LY341495, and [35S]GTP-γ-S binding assays were performed as previously reported (4345, 47). The stoichiometry of 5-HT2AR density (as assessed by [3H]ketanserin binding) and mGluR2 density (as assessed by [3H]LY341495 binding) is similar to that previously observed in native tissue, such as mouse frontal cortex and postmortem human frontal cortex (4345, 47) and in cross-talk positive clones (46).

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