5-HT2AR knockout (Htr2a−/−) mice of 129S6/Sv background have previously been described (93). For experiments involving 5-HT2AR−/− mice, wild-type (5-HT2AR+/+) littermates on a 129S6/Sv background were used as controls. Animals were housed at 12-hour light/dark cycle at 23°C with food and water ad libitum. The Institutional Animal Use and Care Committee at Virginia Commonwealth University School of Medicine approved all the experimental procedures.

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