All animals care and use adhered to the Guide for the Care and Use of Laboratory Animals of the Chinese Association for Laboratory Animal Science. All procedures of animal handling were approved by the Animal Care Committee of Peking University Health Science Center (permit number LA 2016240). The Hipk2+/− mice were a gift from E. J. Huang (University of California, San Francisco). Hipk2+/− mice were bred with Hipk2+/− mice to generate Hipk2−/− mice. Ifnαr−/− mice were a gift from R. Medzhitov (Yale University). Wild-type B6 mice were purchased from the Department of Laboratory Animal Science of Peking University Health Science Center, Beijing. Mice were kept and bred in pathogen-free conditions. All animal results were included, and no method of randomization was applied. Eight-week-old mice were infected with VSV with 1 × 107 PFU of viruses per mouse by intravenous injection. The body weight of the mice was monitored accordingly. For cytokine studies, blood was collected at days 0 and 4 after infection.

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