The following statistical tests were used: paired two-tailed t test (all qRT-PCR, Western blot analysis, and immunofluorescence), χ2 tests (cell cycle analysis), Pearson correlation coefficient (comparison of rates of p-S6 loss versus nuclear Polκ enrichment), two-way analysis of variance (ANOVA), and Fisher’s least significant difference (LSD) test (drug resistance assays).

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