WT C57BL/6J mice were bred at the Benaroya Research Institute or purchased from the Jackson Laboratories. BCAP−/− mice lacking the Pik3ap1 gene were back-crossed to C57BL/6J mice for nine generations (3). Caspase-1/11−/− mice (46) were provided by R. Flavell (Yale University, New Haven, CT). Caspase-11−/− mice (47) were provided by M. Bevan (University of Washington, Seattle, WA). All experiments were performed in accordance with protocols approved by the Institutional Animal Care and Use Committee at the Benaroya Research Institute and the University of Washington.

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