Cell culture experiments were independently repeated at least three times using matched controls. The data were pooled, and statistical analyses were performed. Results are expressed as means ± SD for all in vitro experiments. Statistical analysis of dose-response curves was performed using the Wilcoxon matched-pairs signed-rank test or repeated-measures ANOVA as indicated. Single-dose data were assessed by Student’s t test or by one-way ANOVA, and P values below 0.05 were considered statistically significant. All statistical tests were performed using Prism 7 for Mac OSX (GraphPad Software).

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