Mann-Whitney test, Student t test, one-way ANOVA, and two-way ANOVA were used, and P < 0.05 was considered statistically significant. For multiple testing corrections, Tukey’s post hoc test, Dunnet’s post hoc test, or Sidak’s post hoc test was utilized as indicated in the figure legends and table S2. All the statistical analyses were performed with GraphPad Prism 7 (GraphPad Software Inc.). Detailed values for statistical analysis are provided in table S2.

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