The main research objectives of these studies were to investigate the physiological effects of biased agonists of CXCR3 and determine the mechanisms by which engagement of the β-arrestin–mediated signaling pathway potentiates chemotaxis and inflammation. These studies were performed with a combination of patient leukocytes, patient skin, genetically modified mice, and pharmacologic treatments supported by in vitro mechanistic data. The number of patients and animals used in each group for each experiment is reported in the figure legends. Animals were randomly assigned to treatment groups once their genotypes were confirmed, and investigators were blinded to mouse pharmacological treatments. Statistical details are provided at the end of this section and within the figure legends.

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