To correlate the developmental stages between human retina and RO, we applied OE-DTW analysis (21). DTW is a popular technique for comparing time series. The rationale behind DTW is that given two time series, they should be stretched or compressed locally to make one resemble the other as much as possible. We used the R package DTW on expression profiles of human retinal development spanning from GW6 to GW25. The analysis was performed on the 3235 genes from the human RNA-seq data to find an optimal alignment between the human retinal and RO development.

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