The resulting MS/MS data were processed using MaxQuant with integrated Andromeda search engine (v. Tandem mass spectra were searched against human Swiss-Prot database (20,203 sequences) concatenated with reverse decoy database. Trypsin/P was specified as cleavage enzyme allowing up to four missing cleavages. The mass tolerance for precursor ions was set to 20 parts per million in first search and 5 parts per million in main search, and the mass tolerance for fragment ions was set to 0.02 Da. Carbamidomethyl on Cys was specified as fixed modification, and Kcr modification and oxidation on Met were specified as variable modifications. False discovery rate (FDR) was adjusted to <1%, and minimum score for modified peptides was set to >40.

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