All animal experiments were approved by the local authority, the Lower Saxony State Office for Consumer Protection and Food Safety (Niedersächsisches Landesamt für Verbraucherschutz und Lebensmittelsicherheit) and the institutional ethical boards of the Katholieke Universiteit Leuven. Mixed neuroglial cultures were prepared from P2 Wistar rats. For neuroLNC, cloning and mRNA isolation samples were also collected from Wistar rats at various ages (as indicated in the respective experiments). For in utero electroporation, Swiss mice were used. All human midbrain samples were obtained from the Parkinson’s U.K. Brain Bank (Imperial College London, London, England). Snap-frozen tissue blocks were transported and stored under controlled temperature conditions (−80°C). The samples were conceded to the Department of Neurology of the University Medical Center Göttingen (Göttingen, Germany), and ethical approval was given by the Multicentre Research Ethics Committee (07/MRE09/72).

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