The study was conducted on mouse models as described in the “Experimental models” section to perform in vivo and in vitro laboratory experiments. The sample size was not predetermined. We used a sample size allowing statistical significance to be reached between the different groups. No animals were excluded from the analysis. No technical replicates were used to calculate statistics. No randomization and no blinding were used in this study. For each experiment, we used biological-independent replicates per condition, and the number of replicate has been reported in the legends.

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