Mice bearing 231-Br-Luc intracranial tumors were randomized into four groups (n = 9 per group) 7 days after tumor cell implantation based on BLI measurements. Three groups of mice were given Abraxane, PLGA-PEG-IgG-PTX, or PLGA-PEG-ITEM4-PTX intravenously via tail vein at a single dose of 10 mg/kg PTX. The control group received saline (200 μl) injected intravenously on the same days as the PTX treatments. After drug administration, mouse body weight and tumor growth were monitored every 2 to 3 days. Tumor growth was evaluated via BLI monitoring as described above. Mice were euthanized when body weight dropped more than 20% and/or if animals showed any signs of discomfort or neurological abnormalities. Survival comparisons between groups were analyzed by Kaplan-Meier and the log rank test.

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