Mice bearing 231-Br-Luc intracranial tumors were randomized into four groups (n = 9 per group) 7 days after tumor cell implantation based on BLI measurements. Three groups of mice were given Abraxane, PLGA-PEG-IgG-PTX, or PLGA-PEG-ITEM4-PTX intravenously via tail vein at a single dose of 10 mg/kg PTX. The control group received saline (200 μl) injected intravenously on the same days as the PTX treatments. After drug administration, mouse body weight and tumor growth were monitored every 2 to 3 days. Tumor growth was evaluated via BLI monitoring as described above. Mice were euthanized when body weight dropped more than 20% and/or if animals showed any signs of discomfort or neurological abnormalities. Survival comparisons between groups were analyzed by Kaplan-Meier and the log rank test.

Note: The content above has been extracted from a research article, so it may not display correctly.

Please log in to submit your questions online.
Your question will be posted on the Bio-101 website. We will send your questions to the authors of this protocol and Bio-protocol community members who are experienced with this method. you will be informed using the email address associated with your Bio-protocol account.

We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.