Statistical analysis was performed using GraphPad Prism Software version 8.4. All the in vitro experiments were done in duplicate or triplicate, and values were presented as means ± SD from one of the independent experiment sets. EC50 values were determined using a nonlinear regression curve. Tumor growth curves were shown as means with SEM. The statistical tests used were indicated in the figure legends for each experiment. In the tumor growth curves, only P values on the last day were shown. Asterisks indicated P values as *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.

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