This study was conducted according to the National Health and Medical Research Council (NHMRC) Australian Code for the responsible conduct of Research and the National Statement on Ethical Conduct in Human Research. Patients and healthy donors (H6 to H12) have provided their written informed consent for the research study protocol, which were approved by the Human Research Ethics Committee of the Austin Hospital (Melbourne) and Princess Alexandra Hospital (Brisbane), respectively. Ethics approvals were obtained from The University of Queensland Institutional Human Research Ethics Committee (approval nos. 2011001315 and 2016000876). Healthy donors’ blood samples (H1 to H5) were obtained from Red Cross blood. All blood samples were processed using the same standard protocol in accordance with approved guidelines. The demographic data for all patients and healthy donors have been summarized in table S2.

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