Time to threshold results (τ) were normalized by subtracting τ from the no-antibiotic control yielding a Δτ value. An outlier for both ESBL41 and ESBL168 was removed due to unambiguous plate reader and experimental error, respectively, to preserve data integrity. Triplicate τ measures were parsed with ANOVA in R to reveal significant global interactions among strain, antibiotic, and concentration variables. Tukey post hoc test was performed for significant interactions. All tests are two tailed, and all replicates are technical unless indicated otherwise.

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