Following superficial skin or intraperitoneal infection and/or serum treatment, mice were monitored closely for the development of STSS-related pathology. Clinical scoring was performed blindly as per the scoring system defined by Shrum et al. (32). The scoring system included a number of variables to assess disease severity including appearance, level of consciousness, activity, response to stimulus, eyes, respiration rate, and respiration quality. The mice were scored from 0 to 4, where 0 represented the baseline and 4 was the highest score for each category.

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