Amino acid classifications by physicochemical properties
This protocol is extracted from research article:
Amino acid exchangeabilities vary across the tree of life
Sci Adv, Dec 4, 2019; DOI: 10.1126/sciadv.aax3124

Amino acid classifications by physicochemical properties follow Zhang (44). On the basis of charge, amino acids were classified into three groups: positively charged (R, H, and K), negatively charged (D and E), and neutral (A, N, C, Q, G, I, L, M, F, P, S, T, W, Y, and V). On the basis of polarity, amino acids were classified into two groups: polar (R, N, D, C, Q, E, G, H, K, S, T, and Y) and nonpolar (A, I, L, M, F, P, W, and V). On the basis of volume, amino acids were classified into three groups: small (A, G, P, S, T, N, D, Q, E, I, L, M, and V), large (R, H, K, F, W, and Y), and special (C).

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