Peak calling was performed using MACS2 (55), with the parameters “--slocal=2000 --llocal=50000 --nomodel --extsize=1500 -q .0005 -g hs” on each replicate, and then a calculation of the two sets of peaks union was done. Peaks were then intersected using mergePeaks (HOMER, v4.10) (56), and differential peaks were assigned to nearby genes and analyzed for gene ontology enrichments using GREAT (57).

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