Statistical analyses for CSDE1 LGD variants

De novo significance was calculated using a binomial model that incorporates gene-specific variant rates estimated from an overall rate of variation in coding sequences and estimates the relative locus-specific rates based on the CH model (15) with an expected rate of 1.5 de novo variants per exome. P values were corrected genome-wide for the number of genes (18,946). Burden of CSDE1 LGD variants between patients and ExAC nonpsychiatric samples was performed using Fisher’s exact test. All statistical analyses were performed using the R statistical language (v3.2.4) (www.r-project.org/).

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