Prism 7 was used to perform all statistical analyses (GraphPad Software). Student’s t tests were used to compare two groups (Fig. 3B). Multiple groups were compared using one-way analyses of variance (ANOVAs) with Tukey’s post hoc test (Figs. 4 and 5 and tables S2 and S3). P < 0.05 was considered significant. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. Lines were fit to the data in fig. S2B using linear regression analysis, and correlations were considered significant if the slopes of the linear regression fits were significantly nonzero.

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