P8 littermates of C57BL/6J and Balb/c background were used for this study. No differences in PHH development were observed between strains (fig. S5). Lpar1-5 knockout mice (3539) were crossed onto C57BL/6J (LPA2, LPA4, and LPA5) or Balb/c (LPA1, LPA2, and LPA3) backgrounds. Pups were fostered with WT mothers when the birth mothers demonstrated aggression or knockout mothers could not leave the breeding colony.

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