Phosphorylation of paxillin can promote the formation of FXs and FAs, while pPaxillin/FAK complexes can inhibit the formation of FXs and FAs. This results in a negative feedback loop for integrin clustering. To evaluate the effects of such negative feedback regulation on integrin clustering, we developed an integrated signaling network model containing a series of ordinary differential equations (see model equations and parameters in the Supplementary Materials).

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