The animal protocols used in this work were evaluated and approved by the Institutional Animal Care and Use Committee of the University of Miami (no. 12-276). All activities were performed in compliance with federal state and institutional regulations. The University was granted full accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care, International in February 2005 and received its current reaccreditation in 14 March 2019. In addition, University of Miami is licensed by the U.S. Department of Agriculture and has filed a Letter of Assurance with the Office of Laboratory Animal Welfare, U.S. Department of Health and Human Services.

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