All four experiments used a randomized controlled pretest-posttest design. At pre- and posttreatment assessments, participants completed a laboratory-based cue-reactivity task (described below). In experiments 1 to 3, EEG was recorded during the task. In experiment 4, self-reported affect and craving ratings were obtained during the task. In experiment 4, participants were also assessed with the COMM (38), a validated measure of opioid misuse risk, at pretreatment and again at 3-month follow-up. Across all four experiments, following the pretreatment assessment, participants were randomly assigned by a project staff member who was uninvolved with assessment or treatment to an 8-week MORE group or SG. Random assignment occurred via a computerized random number table generated by a researcher who was uninvolved in assessment, treatment, or enrollment using simple randomization in blocks of varying sizes (two to four) to preserve unpredictability of allocation. The allocation list was stored in a protected file inaccessible to project staff involved in assessment or treatment. Assessments were conducted by project staff blinded to group assignment (which remained concealed throughout the study). Before each assessment, participants were reminded to not disclose their group assignment to study staff to ensure blinding of study personnel.

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