To determine the blood stability of the nanoformulation in vivo, different samples including DOX, ACC@DOX-CaSi, and ACC@DOX-CaSi-PAMAM-FA/mPEG were intravenously injected into mice (n = 3) with no tumor burden, and the equivalent DOX concentration was maintained at 5 mg/kg. Blood (20 μl) was extracted from each mouse at given time points, and the red blood cells were removed via low-speed centrifugation. The DOX fluorescence intensity in the blood samples was then measured on a fluorescence spectrometer.

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