Mice with 4T1 or A375 tumor xenografts were intravenously injected with various sample solutions including Cy5, ACC@Cy5-CaSi, and ACC@Cy5-CaSi-PAMAM-FA/mPEG and imaged on a PerkinElmer in vivo imaging system (IVIS Lumina III) at certain time points. The equivalent Cy5 concentration was maintained at 5 mg/kg.

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