All odorant structures and associated CAS numbers were retrieved from either Sigma-Aldrich ( or PubChem ( Odor descriptors were retrieved using The Good Scents Company database ( A comprehensive list of the cognate mouse and human OR-ligand pairs was assembled (last update: June 2017) by combining the data from the ODORactor database (19) and other literature sources, representing a total of 44 different studies (7, 15, 17, 18, 2029). Human KFOs and mouse SMCs were identified from databases and previously published studies (15, 17, 18, 22, 2533, 59, 60). In addition, we found that the human OR-detecting muscone (OR5AN1) also recognizes the structurally related KFO β-ionone (fig. S4).

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