These studies were approved by the Institutional Review Board of Benaroya Research Institute (BRI, Seattle, WA) and Seattle Children’s Hospital. All DQ8+DQ2 and DQ8+DQ2+ participants were volunteers of Caucasian descent and were recruited with written consent from participating individuals or assent and the consent of their guardians if participants were minors (tables S2 and S3). HLA typing was conducted by the BRI sequencing and genotyping core facilities. Autoantibodies were measured at the Barbara Davis Center for Childhood Diabetes.

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