The data analysis methods used in this work are substantially the same as those developed in the neuroscience community to analyze microelectrode array recordings from biological brain tissue (2427). Events are defined as changes in the conductance signal that exceed a threshold value. We show in fig. S3 that, as in the neuroscience literature, the choice of threshold in a reasonable range does not significantly affect the avalanche analysis. Avalanches were defined following the procedure described in (24, 45): The data were analyzed by defining time bins with width equal to the mean IEI (24), and the duration of the avalanche was defined as the number of consecutive nonempty bins between empty bins. Figure S4 shows the effect of bin size on the avalanche analysis.

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