All procedures were performed following the guidelines of the Institutional Animal Care and Use Committee and in compliance with the Animal Welfare Act, the Guide for the Care and Use of Laboratory Animals, the Office of Laboratory Animal Welfare, and the guidelines of Massachusetts General Hospital. The animals’ living conditions, including housing, feeding, and nonmedical care, were maintained by the house internal animal facility (CCM). For the comparison between GFP-2a-WTtau– and GFP-2a-P301Ltau–expressing mice, 8- to 10-month-old male WT (C57BL/6, the Jackson Laboratory) mice were used. For the comparison of young (3 months old) versus old (22 to 24 months old) mice, male C57BL/6 WT mice of the respective ages were purchased from the National Institute of Aging (NIA).

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