SNP heritability
AA Alexessander Couto Alves NS N. Maneka G. De Silva VK Ville Karhunen US Ulla Sovio SD Shikta Das HT H. Rob Taal NW Nicole M. Warrington AL Alexandra M. Lewin MK Marika Kaakinen DC Diana L. Cousminer ET Elisabeth Thiering NT Nicholas J. Timpson TB Tom A. Bond EL Estelle Lowry CB Christopher D. Brown XE Xavier Estivill VL Virpi Lindi JB Jonathan P. Bradfield FG Frank Geller DS Doug Speed LC Lachlan J. M. Coin ML Marie Loh SB Sheila J. Barton LB Lawrence J. Beilin HB Hans Bisgaard KB Klaus Bønnelykke RA Rohia Alili IH Ida J. Hatoum KS Katharina Schramm RC Rufus Cartwright MC Marie-Aline Charles VS Vincenzo Salerno KC Karine Clément AC Annique A. J. Claringbould CD Cornelia M. van Duijn EM Elena Moltchanova JE Johan G. Eriksson CE Cathy Elks BF Bjarke Feenstra CF Claudia Flexeder SF Stephen Franks TF Timothy M. Frayling RF Rachel M. Freathy PE Paul Elliott EW Elisabeth Widén HH Hakon Hakonarson AH Andrew T. Hattersley AR Alina Rodriguez MB Marco Banterle JH Joachim Heinrich BH Barbara Heude JH John W. Holloway AH Albert Hofman EH Elina Hyppönen HI Hazel Inskip LK Lee M. Kaplan AH Asa K. Hedman EL Esa Läärä HP Holger Prokisch HG Harald Grallert TL Timo A. Lakka DL Debbie A. Lawlor MM Mads Melbye TA Tarunveer S. Ahluwalia MM Marcella Marinelli IM Iona Y. Millwood LP Lyle J. Palmer CP Craig E. Pennell JP John R. Perry SR Susan M. Ring MS Markku J. Savolainen FR Fernando Rivadeneira MS Marie Standl JS Jordi Sunyer CT Carla M. T. Tiesler AU Andre G. Uitterlinden WS William Schierding JO Justin M. O’Sullivan IP Inga Prokopenko KH Karl-Heinz Herzig GS George Davey Smith PO Paul O'Reilly JF Janine F. Felix JB Jessica L. Buxton AB Alexandra I. F. Blakemore KO Ken K. Ong VJ Vincent W. V. Jaddoe SG Struan F. A. Grant  SS Sylvain Sebert  MM Mark I. McCarthy  MJ Marjo-Riitta Järvelin

We estimated the SNP heritability, the proportion of variance explained by common SNPs (MAF > 1%), with LD score as implemented in LD hub and using our six stage 1 GWAS meta-analyses on early growth traits (see the next paragraph for detailed information on postprocessing of GWAS data for LD score analysis). LD score regression estimates were obtained using a regression model with intercept, which aims at correcting for systematic confounders in GWAS summary statistics such as population stratification. In addition, we provided SumHer (21) SNP heritability estimates due to the current debate on the (mainly downward) bias of LD score regression estimates. SumHer estimates were obtained using a regression model including an intercept. The estimates of heritability using family and twin studies were obtained from the literature using PubMed searches complemented with Google scholar. The proportion of heritability explained by common SNPs is the ratio of the SNP heritability obtained from LD score regression and the overall heritability obtained from family and twin studies.

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