Adult BMI GRS
AA Alexessander Couto Alves NS N. Maneka G. De Silva VK Ville Karhunen US Ulla Sovio SD Shikta Das HT H. Rob Taal NW Nicole M. Warrington AL Alexandra M. Lewin MK Marika Kaakinen DC Diana L. Cousminer ET Elisabeth Thiering NT Nicholas J. Timpson TB Tom A. Bond EL Estelle Lowry CB Christopher D. Brown XE Xavier Estivill VL Virpi Lindi JB Jonathan P. Bradfield FG Frank Geller DS Doug Speed LC Lachlan J. M. Coin ML Marie Loh SB Sheila J. Barton LB Lawrence J. Beilin HB Hans Bisgaard KB Klaus Bønnelykke RA Rohia Alili IH Ida J. Hatoum KS Katharina Schramm RC Rufus Cartwright MC Marie-Aline Charles VS Vincenzo Salerno KC Karine Clément AC Annique A. J. Claringbould CD Cornelia M. van Duijn EM Elena Moltchanova JE Johan G. Eriksson CE Cathy Elks BF Bjarke Feenstra CF Claudia Flexeder SF Stephen Franks TF Timothy M. Frayling RF Rachel M. Freathy PE Paul Elliott EW Elisabeth Widén HH Hakon Hakonarson AH Andrew T. Hattersley AR Alina Rodriguez MB Marco Banterle JH Joachim Heinrich BH Barbara Heude JH John W. Holloway AH Albert Hofman EH Elina Hyppönen HI Hazel Inskip LK Lee M. Kaplan AH Asa K. Hedman EL Esa Läärä HP Holger Prokisch HG Harald Grallert TL Timo A. Lakka DL Debbie A. Lawlor MM Mads Melbye TA Tarunveer S. Ahluwalia MM Marcella Marinelli IM Iona Y. Millwood LP Lyle J. Palmer CP Craig E. Pennell JP John R. Perry SR Susan M. Ring MS Markku J. Savolainen FR Fernando Rivadeneira MS Marie Standl JS Jordi Sunyer CT Carla M. T. Tiesler AU Andre G. Uitterlinden WS William Schierding JO Justin M. O’Sullivan IP Inga Prokopenko KH Karl-Heinz Herzig GS George Davey Smith PO Paul O'Reilly JF Janine F. Felix JB Jessica L. Buxton AB Alexandra I. F. Blakemore KO Ken K. Ong VJ Vincent W. V. Jaddoe SG Struan F. A. Grant  SS Sylvain Sebert  MM Mark I. McCarthy  MJ Marjo-Riitta Järvelin

We calculated a weighted GRSs of adult BMI with the 97 SNPs associated with BMI at genome-wide levels of significance in the GIANT consortium (18) using the R package gtx and following the procedure described in (58). Briefly, a risk score estimating the pleiotropic effect of adult BMI variants on each early growth trait was inferred from summary statistics obtained from the stage 1 GWAS meta-analyses. Risk score models with evidence of heterogeneity (Phet < 0.05, only BMI-AP) were refitted using a downwards elimination of SNPs with largest effect size until the model is not heterogeneous (Phet > 0.05). In addition, we estimated evidence of horizontal pleiotropy between adult BMI and each early growth trait with the package MR-PRESSO (59).

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