Transcript counts were transformed to z-normalized TPM. MetaGene values were then generated by computing the mean z score across all genes in each gene set (GS-1 to GS-19) for each cell. Cluster-specific MetaGene expression was designated high (pink) if mean expression exceeded 1 SD above the mean value across all cells, medium (white) if mean expression exceeded one-half of an SD above the mean value across all cells, and low (light gray) if mean expression exceeded the mean value across all cells. Cluster-specific mean expression below the mean value across all cells indicated that a given cluster did not express a given gene set (dark gray).

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