A gene set enrichment analysis was performed to look for enriched gene functions in the recombinant regions. The BiNGO tool (56) was used to study the enrichment in certain functional categories comparing the most abundant terms in the recombinant regions with those contained in the complete annotation. The tool uses a hypergeometric test (sampling without replacement) and the BH (Benjamini-Hochberg) correction for multiple testing comparisons.

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