To examine the efficacy of GO on delivering the membrane-specific drugs, the tyrosine kinase inhibitors were selected as the cargo, and classical liposome was used as a control carrier. Drugs (1 mg) were loaded on GO by using a simple adsorption method, and the loading efficiency was 73 and 74% for VTB and regorafenib (REGO), respectively. For drug-loaded liposomes, 1 mg of drug solution is primarily added to the liposome powder solvent (8 mg of DC-cholesterol and 2 mg of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) phospholipid were dissolved in chloroform). Subsequently, liposomes (~100 nm) were prepared following a typical procedure, including lipid hydration, stirring, and downsizing.

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