In vivo experiments were carried out in France at the Institute for Advanced Biosciences (Grenoble) and the Institute of Biology and Chemistry of Proteins (Lyon). These laboratories are certified by the French Ministry of Research and Education Superior and regularly monitored by the French Departmental Directorate for the Protection of Population (approval numbers C 69 123 0303 and C38 516 10001). Immunization studies were carried out at the Institute of Virology, Biomedical Research Centre, Slovak Academy of Sciences (Bratislava). Animal care was in compliance with the standard operation procedures of the Institute of Virology and the European Convention for the Protection of Vertebrate Animals used for experimental and other scientific purposes (ETS 123) with approval from the Veterinary State Administration, Slovak Republic (Statna veterinarna a potravinova sprava Slovenskej republiky), and institutional ethical committee. All animal experiments were carried out according to the rules in force and in the respect of the ethics of the animal experimentation.

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