Homology modeling was performed using I-TASSER (33) using the human adenovirus Ad3 structure as template (17). The model was adjusted to fit into the map manually using COOT (34) before further iterative positional and B factor refinement in real space using Phenix Real-Space refinement software (35). Final adjustments were carried out in COOT before evaluating the model using MolProbity (36). Refinement statistics are summarized in table S1.

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