Oligopeptides were prepared by standard liquid-phase peptide synthesis. N-Boc oligopeptides were then subjected to 4 M HCl/dioxane for 4 hours at 0°C. Upon completion, the reaction mixture was concentrated and extracted with dichloromethane three times. The organic layer was combined, dried over anhydrous Na2SO4, and concentrated under vacuum. The resulting residue was purified with column chromatography to yield oligopeptide with a free amine at the N terminus. The oligopeptides were then coupled with 2-(o-tolyl)acetic acid to yield corresponding peptidoarylacetamides.

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