Cell lines
Antibodies
Protein extraction and coimmunoprecipitation
Histone extraction
ChIP-MS and data analysis
ChIP, sequencing, and data analysis
Nascent RNA, total RNA, and mRNA sequencing, microarrays, and data analyses
Gene set enrichment analysis
Functional analyses
Enhancer RNA expression analysis
Cell proliferation, cell cycle, and annexin V assays
qPCR
DOT1L knockdown
Miniaturized organotypic 3D cultures
Xenograft experiments
Statistical analyses were performed using R (version 3.4.4). Error bars represent means ± SD. For animal studies, statistical differences between groups were determined using unpaired two-sample t test. Values of P ≤ 0.05 were considered to be statistically significant.