Mouse experiments were conducted with the approval of the Regierung von Oberbayern, Munich, Germany (Az 55.2.1.54-2532-90/12 and 177/15). The clinical study was approved by the Ethics Committee of Shanghai General Hospital (ethics #2018KY153) and was performed according to the Declaration of Helsinki Principles. Written consent to notify blood and bone marrow samples to be applied for future research was obtained for each patient under Institutional Review Board–approved protocol.

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